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Head-to-head verdict

Synergy Rx vs Sesame Care

Two GLP-1 providers, ruled side by side on The Verdict Score — our published six-factor rubric. Same yardstick, and no score is adjusted for payment.

Grade C · #34

Synergy Rx

Will prescribe brand Wegovy, Ozempic or Mounjaro when clinically appropriate, with unlimited round-the-clock access to its clinical team.

Visit Synergy Rx
vs
WinnerGrade B+ · #4

Sesame Care

An established national telehealth marketplace with the widest real brand-name GLP-1 access on the board — Wegovy (pen and pill), Zepbound, Ozempic and Mounjaro — plus provider-by-provider price transparency.

Visit Sesame Care

The verdict

Winner: Sesame Care

Sesame Care takes it with a higher Verdict Score — 87/100 to 79/100 (grade B+ vs C). Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program. Synergy Rx still earns its place — people who specifically want a brand-name path and as much clinician contact as they can get, and who will accept getting pricing by enquiry.

Neither of these is our overall #1. That title goes to CoreAge Rx (94/100) — the most honest middle of the market: nationwide access, both molecules at one flat, no-surprise price.

Factor by factor

Both scored on the same six factors — see the methodology. The brass bar marks the stronger side on each.

76Real-world results86
58Price honesty80
92Prescriber access92
90Formulary choice95
70Cancellation fairness82
90Member support80

Price, coverage & features

MetricSynergy RxSesame Care
Verdict Score79/10087/100
GradeCB+
SemaglutideFrom $199/moFrom $149/mo (brand Wegovy pill)
TirzepatideFrom $349/moBrand Zepbound (price varies)
CoverageNot disclosedNationwide marketplace
Brand-name accessYesYes
Oral / sublingualNoYes

Synergy Rx

What we like

  • Prescribes FDA-approved brand Wegovy, Ozempic and Mounjaro when clinically appropriate — rare on this board
  • Unlimited appointments, unlimited messaging and 24/7 access to a dedicated clinical team
  • A $100 welcome credit applied at checkout, and FSA/HSA eligible

The caveats

  • Publishes no GLP-1 price anywhere on its own site — it prices its longevity line openly and the medication this page is about not at all
  • At $349/mo, tirzepatide sits roughly $100 above the compounded median we track
  • Does not publish which states it serves
  • No published cancellation or refund terms

Sesame Care

What we like

  • Real FDA-approved brand-name access — Wegovy pen and pill, Zepbound, Ozempic, Mounjaro and Rybelsus
  • Established platform (operating since 2018) with LegitScript, BBB accreditation and large third-party review volume
  • You choose the provider and see the price up front — genuine marketplace transparency
  • Oral routes available (Wegovy pill, Rybelsus)

The caveats

  • A generalist marketplace, not a dedicated weight-loss program — lighter ongoing hand-holding than a specialist desk
  • Two-part cost (a platform subscription plus the medication) makes the true monthly total harder to compare
  • Brand-name cash prices can run high without insurance

Also worth a look

People who specifically want a brand-name path and as much clinician contact as they can get, and who will accept getting pricing by enquiry.

Visit Synergy Rx Read the full Synergy Rx review →

Our pick — visit

Shoppers who want genuine FDA-approved brand-name GLP-1s and the ability to pick their own provider and see the price up front, rather than one fixed compounded program.

Visit Sesame Care Read the full Sesame Care review →

Keep comparing

Or browse the full comparison hub and the complete rankings.

Pricing, states and verification reflect each provider's public disclosures at last review; the Verdict Score is our editorial judgment per the methodology. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.